Detection of chromosomal aberrations in multiple myeloma with fluorescence in situ hybridization / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 983-989, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-814752
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To detect of chromosomal abnormalities in multiple myeloma (MM) patients with fluorescence in situ hybridization (FISH).@*METHODS@#FISH was performed in 20 MM patients using 5 specific DNA probes. The difference in chromosomal abnormalities was compared by FISH and other routine cytogenetic tests.@*RESULTS@#Eighteen of the 20 patients showed chromosomal abnormalities (90%). The positive rates of t(14q32), del(13q14), dup(1q21), and p53 gene were 65% (13 in 20), 55% (11 in 20), 25% (5 in 20), and 15%(3 in 20), respectively. The abnormal rate of the conventional chromosome examination was 15% only.@*CONCLUSION@#FISH is more sensitive than traditional chromosomal tests and can be used as an index in prognostic evaluation for MM. Del(13q14) and t(14q32) are the most common chromosomal abnormalities in MM patients.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Cromossomos Humanos Par 1
/
Cromossomos Humanos Par 13
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Cromossomos Humanos Par 14
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Aberrações Cromossômicas
/
Hibridização in Situ Fluorescente
/
Genética
/
Mieloma Múltiplo
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2012
Tipo de documento:
Artigo