Diagnosis and treatment of warfarin resistance / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 313-317, 2013.
Article
em Zh
| WPRIM
| ID: wpr-814883
Biblioteca responsável:
WPRO
ABSTRACT
Warfarin resistance is a phenomenon that patients need to take much higher than normally prescribed dosage of warfarin to maintain the target therapeutic international normalized ratio (INR) range, or even fail to reach the target INR. Warfarin resistance can be categorized in etiologic terms as hereditary vs acquired, or in pharmacologic terms as pharmacokinetic vs pharmacodynamic. Once warfarin resistance is diagnosed, the type of resistance should be determined as soon as possible so that treatment could be oriented toward the causes. Poor compliance, genetic mutations, concurrent medications that could decrease the absorption or increase the clearance of warfarin, and consumption of diet rich in vitamin K are the major reasons for warfarin resistance. Educating patients, increasing warfarin dosage and switching to other anticoagulants would be effective for warfarin resistance.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Vitamina K
/
Monitoramento de Medicamentos
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Coeficiente Internacional Normatizado
/
Diagnóstico
/
Vitamina K Epóxido Redutases
/
Genética
/
Erros Inatos do Metabolismo
/
Métodos
/
Anticoagulantes
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2013
Tipo de documento:
Article