Research progress in the role of small RNA fragments derived from tRNA in malignant tumors / 医学研究生学报
Journal of Medical Postgraduates
; (12): 412-417, 2019.
Article
em Zh
| WPRIM
| ID: wpr-818252
Biblioteca responsável:
WPRO
ABSTRACT
Noncoding small RNAs are the important regulators of vital processes. Through the high-throughput sequencing and analyses of small RNA fragments, a new class of non-coding small RNAs has been presented, which can be matched to the known tRNA gene. The different sources of tRFs are classified into various types depending on where they match on the parental tRNA. The tRFs can be expressed in a variety of organisms. Recent studies have found that the tRFs have a variety of biological functions in the regulation of gene expression, epigenetics,tumor suppression, neurodegeneration and so on. As a regulatory RNA, the tRFs play an important role in development and progression of tumors, and are known to play regulatory roles in the proliferation and metastasis of tumor cells. This article reviews the research progress on the classification,biological function and role of tRFs in malignant tumors.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2019
Tipo de documento:
Article