Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats

ABSTRACT

OBJECTIVE@#To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.@*METHODS@#Sixty Wistar rats were randomly divided into four groups. The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method. Rats in A and B groups were intragastrically administered with physiological saline, while C and D groups were administered with Xinjikang and metoprolol, respectively. The changes in blood pressure, E/A ratio, myocardial pathological morphology, myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.@*RESULTS@#There were statistically significant differences in E/A ratio between C group after treatment and model group (P0.05); after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group (P<0.05).@*CONCLUSIONS@#Xinjikang can improve myocardial injury, restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.