Effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris
Asian Pacific Journal of Tropical Medicine
; (12): 668-670, 2014.
Article
em En
| WPRIM
| ID: wpr-820634
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris.@*METHODS@#A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome differentiation of TCM and randomized controlled method: wind heat syndrome group (group A), blood stasis syndrome group (group B), blood dryness syndrome group (group C) and control group (group D) (n=30 per group). Patients in observation groups were treated with Yinxieling decoction, while patients in control group were treated by placebo for 8 weeks. Levels of TNF-α and IL-8 were determined before treatment, 4 and 8 weeks after treatment. psoriasis area and severity index score was also performed before and after treatment.@*RESULTS@#psoriasis area and severity index score and serum level of TNF-α, IL-8 were significantly decreased in all groups. The decrease in three observation groups was more significant (P<0.05 or P<0.01), and the decrease in wind heat syndrome group was the most significant (P<0.01). psoriasis area and severity index was positively correlated with TNF-α and IL-8, respectively (P<0.05).@*CONCLUSIONS@#Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulating TNF-α and IL-8.
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Psoríase
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Sangue
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Índice de Gravidade de Doença
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Medicamentos de Ervas Chinesas
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Epidemiologia
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Interleucina-8
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Fator de Necrose Tumoral alfa
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Resultado do Tratamento
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Classificação
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2014
Tipo de documento:
Article