Comparison of the ratio of plasma aldosterone to renin concentrationmeasured by two chemiluminescent immunoassays in screening for primary aldosteronism / 中华内分泌外科杂志

ABSTRACT

Objective To compare the detection efficiency of the ratio of plasma aldosterone concentra-tion to renin concentration (ARR) measured by imported and domestic chemiluminescent immunoassay kits for screening primary aldosteronism (PA). Methods A total of 164 patients with essential hypertension and 64 pa-tients with PA were recruited in this study. Plasma aldosterone concentration (PAC) and renin concentration (PRC) were measured concurrently by imported chemiluminescent immunoassay kit(Diasorin, Italy) and domestic kit (Mindray, Shenzhen, China), and then ARR were calculated. A ROC curve analysis was performed to compare the screening efficacy of the two kits and the optimal ARR cut-offs for PA screening were recommended according to Youden's index. Results The areas under the ROC curves (AUCROC) of ARR were 0.937 (95％ CI 0.897-0.965, P<0.0001) detected by imported kit and 0.942 (95％ CI 0.903-0.968, P<0.0001) detected by domestic kit. The difference of AUCROC of ARR detected by two kits was 0.00457 (95％ CI -0.0210-0.0302, P<0.7263).The highest Youden's indexes of ARR were 0.749 (detected by imported kit) with the cut-off value of 12.8(pg/ml)/(μIU/ml)(sensitivity 96.87％, specificity 78.05％) and 0.756 (detected by domestic kit) with the cut-off value of 12.5 (pg/ml)/(μIU/ml)(sensitivity 89.06％, specificity 86.59％). Conclusions There was no significant difference between domestic and imported chemiluminescent immunoassays in the screening efficiency of ARR for PA.