Value of MiR-155 in Prognostic Evaluation of Elderly Patients with Primary Immune Thrombocytopenia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1338-1343, 2020.
Article
em Zh
| WPRIM
| ID: wpr-827115
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore the value of has-microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMNC) in prognostic evaluation of elderly patients with primary immune thrombocytopenia (PITP).@*METHODS@#One hundred and thirty elderly PITP patients and 60 healthy volunteers in our hospital were selected. The relative expression level of miR-155 in PBMNC was detected by RT-PCR. Unconditional logistic multivariate regression analysis was used to analyze the relationship between miR-155 expression and prognosis of PITP patients, and Kaplan-Meier was further used to analyze the relationship between miR-155 and PITP recurrence.@*RESULTS@#The relative expression level of miR-155 in PBMNC of elderly PITP patients was significantly higher than that in healthy volunteers, and increased significantly with the severity of the disease (P<0.05). The overall effective rate of elderly PITP patients with miR-155 low-expression was significantly higher than that in the patients with miR-155 high-expression (96.92% vs 72.31%) by after treatment with glucocorticoid. Multivariate analysis showed that miR-155 was an independent risk factor for PITP patients. Elderly patients with high expression of miR-155 showed a higher risk of recurrence.@*CONCLUSION@#miR-155 in PBMNC has a high accuracy for PITP diagnosis, and the elderly patients with high level of miR-155 show a poor prognosis and a higher risk of recurrence.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Prognóstico
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Leucócitos Mononucleares
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Biomarcadores Tumorais
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Púrpura Trombocitopênica Idiopática
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MicroRNAs
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Estimativa de Kaplan-Meier
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Recidiva Local de Neoplasia
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2020
Tipo de documento:
Article