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Hematopoietic Stem Cells Differentiate into the Megakaryocyte Lineage--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1044-1048, 2020.
Article em Zh | WPRIM | ID: wpr-827164
Biblioteca responsável: WPRO
ABSTRACT
Abstract  Hematopoietic stem cells are able to self-renewal and differentiate to all blood lineages. With the development of new technologies, recent studies have proposed the revised versions of hematopoiesis. In the classical model of hematopoietic differentiation, HSCs were located at the apex of hematopoietic hierarchy. During differentiation process, HSCs progressively lose self-renewal potential to be commited to progenitors with restricted differentiation potential. For instance, HSCs first give rise to multipotent progenitor cells, then produce bipotent and unipotent progenitors, and finally differentiate to mature blood cells. For the differentiation of megakaryocytes, common myeloid progenitors derived from HSCs give rise to megakaryocyte-erythrocyte progenitors and then develop to megakaryocytes. However, recent results show that megakaryocytes can be directly generated from HSCs without multipotent or bipotent phases. Alternatively, platelet-biased HSCs produce megakaryocyte progenitors. In this article, recent advances in the hematopoiesis and megakaryocyte differentiation pathway are reviewed.
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Células-Tronco Hematopoéticas / Megacariócitos / Diferenciação Celular / Linhagem da Célula / Células-Tronco Multipotentes / Hematopoese Idioma: Zh Revista: Journal of Experimental Hematology Ano de publicação: 2020 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Células-Tronco Hematopoéticas / Megacariócitos / Diferenciação Celular / Linhagem da Célula / Células-Tronco Multipotentes / Hematopoese Idioma: Zh Revista: Journal of Experimental Hematology Ano de publicação: 2020 Tipo de documento: Article