Research progress on intrinsic signaling pathways in axon regeneration / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 82-89, 2020.
Article
em Zh
| WPRIM
| ID: wpr-828540
Biblioteca responsável:
WPRO
ABSTRACT
The intrinsic regrowth ability of injured neurons is essential for axon regeneration and functional recovery. Recently, numerous intrinsic pathways that regulate axon regeneration have been discovered, among which the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway are arguably the best characterized examples. MAPK signaling pathway is involved in multiple processes including sensing injury signals, initiating and promoting axonal regrowth through regulating cytoskeleton dynamics and protein synthesis. The PI3K/Akt signaling pathway regulates axon regeneration mainly through gene transcription and translation. Combinatory manipulation of multiple regeneration-promoting signals can further improve the extend of axonal regrowth. This paper summarizes current progresses on axon regeneration studies in various organisms and discuss their potentials in promoting functional recovery .
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fisiologia
/
Regeneração
/
Axônios
/
Transdução de Sinais
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Fosfatidilinositol 3-Quinases
/
Regeneração Nervosa
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Neurônios
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2020
Tipo de documento:
Article