Immunological Characteristics and Management of Kidney Transplantation / 대한내과학회지
Korean Journal of Medicine
; : 18-26, 2020.
Article
| WPRIM
| ID: wpr-836660
Biblioteca responsável:
WPRO
ABSTRACT
Kidney transplantation (KT) is the best way to improve the quality of life and survival of patients with end-stage renal disease. However, after KT the adaptive immune system plays important roles in the development of rejection via multiple pathways. Accordingly, the suppression or modulation of these pathways is key to allograft survival. Advances in our understanding of the immunology related to KT with the development of immunosuppressants have reduced the rate of acute rejection and improved short-term transplant outcomes. Nonetheless, de novo donor-specific antibodies and subsequent chronic rejection continue to be responsible for the poor long-term survival of transplanted patients. In addition, the morbidity and mortality rates in patients returning to dialysis after graft failure are high. Better long-term outcomes following KT require innovative treatment strategies that include a focus on de novo antibodies. Here, we review basic transplant immunology as well as the diagnostic tools and medications that contribute to successful KT. We also provide an update on newly developed immunosuppressants.
Texto completo:
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Base de dados:
WPRIM
Aspecto:
Patient_preference
Revista:
Korean Journal of Medicine
Ano de publicação:
2020
Tipo de documento:
Article