Exploring the relationship between blood glucose and arteriosclerosis based on propensity score matching / 上海交通大学学报（医学版）

ABSTRACT

Objective : To explore the relationship between blood glucose and arteriosclerosis with cardio-ankle vascular index (CAVI) as the indicator of arteriosclerosis. Methods ¡¤ From 2016 to 2018, a total of 8 547 participants aged 18 years and above who completed physical examinations in the Physical Examination Center of the First Affiliated Hospital of Chongqing Medical University were selected to collect CAVI and other relevant biochemical indicators. Based on fast blood glucose (FBG) and history of diabetes, the subjects were divided into normal blood glucose group and hyperglycemia group. The 1:1 propensity score matching was used to match the gender, age, blood pressure, blood li-pids, and body mass index to balance the covariates between the groups. The matched data were analyzed by Logistic regression and restricted cubic spline (RCS) to explore the relationship and the dose-effect relationship between FBG and CAVI. Results ¡¤ A total of 1 463 pairs com-pleted propensity score matching, and the covariates between the two groups were balanced after matching. Logistic regression analysis showed that hyperglycemia was a risk factor of CAVI (OR=1.63, 95% CI 1.36-1.95). The RCS curve of FBG and CAVI abnormal risk showed an up-ward trend, i.e., as FBG increased, the risk of CAVI abnormalities increased. Conclusion ¡¤ As the fasting blood glucose increases, the risk of arteriosclerosis also increases.