Correlation between preoperative blood glucose level and clinicopathologic characteristics of pancreatic cancer / 西安交通大学学报(医学版)

ABSTRACT

Objective: To analyze the clinicopathologic characteristics of pancreatic cancer patients and explore the relationship between preoperative blood glucose level and prognosis of pancreatic cancer. Methods: The clinical data of 267 patients treated in The First Affiliated Hospital of Xi'an Jiaotong University from January 2015 to September 2016 were collected and retrospectively analyzed. We also studied the correlation between preoperative blood glucose level and clinicopathologic characteristics of pancreatic cancer. Results: For the study we selected 110 patients (68 males and 42 females) aged between 41 and 84 years with the mean age of (61.34±10.33) years. Among them, 74 (67.27%) of them had preoperative blood glucose level (>6.1 mmol/L) higher than normal level. In addition, 57 patients (51.81%) and 33 patients (30.0%) had CEA level and CA125 level significantly higher than normal and 83 patients (75.45%) had higher CA199 level. There were 56 patients (50.91%)with tumor size over 3 cm and 73 (66.36%) with the tumor located in the head of pancreas. There were 92.73% of patients diagnosed with adenocarcinoma, 2.73% with squamous carcinoma, 2.73% with adenosquamous carcinoma and 1.81% with mucinous cystadenocarcinoma. As for pathological grading, there were 6 cases diagnosed with highly differentiated tumors, 65 cases moderate, 12 moderate to low differentiated, and 27 lowly differentiated tumors. For clinical stage, 2, 13, 27, 20, 15 and 33 patients were detected in stage A, IIIB, ⅡA, ⅡB, III and , respectively. In addition, there were 19 patients detected with lymph node metastases, 22 with distal metastases and 22 with neural invasion. All the 110 patients were followed up effectively, with the average follow-up duration of (4.6±3.8) months. Until the last time we followed up all the patients, we found the tumor relapsed in 14 patients. The median survival time of patients with normal blood glucose was 10 months, while it was only 4 months in patients with high blood glucose. Preoperative blood glucose level was closely related with the patients' prognosis and tumor size, TNM stage, distal metastasis, lymph node metastasis, and neural invasion. Conclusion: High blood glucose level is one of the risk factors for the poor prognosis of pancreatic cancer.