Influence of CYP3A and MDR1 genetic polymorphisms on the pharmacokinetics of ciclosporin A / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 148-151, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-845668
Biblioteca responsável:
WPRO
ABSTRACT
Ciclosporin A (CsA). an immunosuppressive macrolide antibiotics, is widely applied to prevent rejections after organ transplants. CsA is mainly transported by P-glycoprotein (P-gp) and metabolized by cytochrome P450 (CYP450) 3A.Genetic polymorphisms of CYP3A and MDRl probably influence the expressions and bioactivity of CYP3A and P-gp.and may affect the pharmacokinetics of CsA.This issue summarizes the correlation between genetic polymorphisms of CYP3A and MDRl and the pharmacokinetics of CsA to guide the rational and individualized medication.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2015
Tipo de documento:
Artigo