A new glycosyl ester isolated from marine-derived Penicillium sp / 中草药

ABSTRACT

Objective: To isolate and identify the active natural products of marine-derived Penicillium sp. H1. Methods: The isolations and purifications of secondary metabolites were performed by means of column chromatography over silica gel. And their structures were elucidated through the spectroscopic analysis of MS, NMR, and specific rotations. The bioactivities were assayed by paper diffusion. Results: From the fermentation broth of marine-derived Penicillium sp. H1, five compounds were isolated and identified as xylarinonericin E (1), fumitremorgin C (2), verruculogen (3), penicillide (4), and pyripyropene A (5), respectively. Compound 1 showed moderate antifungal activity against Fusarium oxysporum f. sp. Cubense with MIC value of 32.0 μmol/mL. Compound 2 displayed antibacterial activity against Staphylococcus aureus with MIC value of 64.0 μg/mL. Conclusion: Compound 1 is a new compound. Compounds 1 and 2 exhibit moderate antimicrobial activities.