Secondary metabolites from marine fungus Penicillium sp. SCS-KFD16 / 中草药
Chinese Traditional and Herbal Drugs
; (24): 5029-5033, 2018.
Article
em Zh
| WPRIM
| ID: wpr-851582
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the secondary metabolites of the marine fungus Penicillium sp. SCS-KFD16. Methods The metabolites were isolated and purified by silica gel, ODS column, and preparative HPLC methods. The structures of the compounds were identified by MS and NMR spectral data analysis. The DPPH radical scavenging, acetylcholinesterase, and α-glucosidase inhibitory activities of compounds were evaluated by DPPH method, Ellman colorimetric method, and PNPG method, respectively. Results Six compounds were isolated from the EtOAc extract of the fermentation broth of the marine fungus Penicillium sp. SCS-KFD16, and they were identified as 2-(4-hydroxy-2-methoxybenzyl)-5-methoxyphenol (1), penicillide (2), bioxanthracene 2 (3), 6-ethyl-2,4-dihydroxy-3-methylbenzaldehyde (4),4-(2-hydroxyethyl) phenol (5), and 2-(4-hydroxyphenethyl) acetate (6), respectively. Conclusion Compound 1 is a new compound named penicinol. Compounds 2-6 show DPPH radical scavenging activity and compound 4 exhibits inhibitory activity against α-glucosidase with an IC50 value of 24.4 μmol/L.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2018
Tipo de documento:
Article