Application of transcriptomic technologies in hepatotoxicity induced by Chinese materia medica / 中草药

ABSTRACT

As a science of cell genetic transcription and transcriptional regulation at the unitary level, transcriptomics has been applied in basic medicine, biology, microbiology, pharmacy, and so on. In the study on Chinese materia medica (CMM), transcriptomics is used to evaluate the efficacy and toxicity by comparing the changes of gene expression profile before and after drug treatment. To provide the valuable references for the research the development of transcriptomic technology, this article reviewed the progress of its application in CMM research, especially in biomarker screening and mechanism elucidating on the hepatotoxicity induced by CMM.