Relationship between acute hyperglycemia and prognosis in patients following spontaneous intracerebral hemorrhage / 中国脑血管病杂志

ABSTRACT

Objectives: To investigate the relationship between acute hyperglycemia level and prognosis in patients following spontaneous intracerebral hemorrhage. Methods: A total 661 consecutive patients with acute intracerebral hemorrhage (from symptom onset to hospital and evaluated ≤24 hours) were admitted to West China Hospital, Sichuan University from March 1, 2002 to March 1, 2009 were recruited prospectively. The blood glucose levels of the patients and other clinical materials related to the prognosis were collected comprehensively. Hyperglycemia was defined as the blood glucose level ≥8 mmol/L at admission. The mortality and disability (as modified Rankin scale ≥3) of the patients 1 year after intracerebral hemorrhage were followed up. Multivariate logistic regression was used to analyze the relationship between hyperglycemia and prognosis. Results: A total of 661 patients with intracerebral hemorrhage were recruited. Circled digit oneOf the patients, 194 (29.3%) had hyperglycemia and 65 (9.8%) had diabetes mellitus. Circled digit twoThe National Institutes of Health Stroke Scale (NIHSS) score were positively correlated with the admission random blood glucose levels significantly (r = 0.392, P = 0.000). Circled digit threeCompared to the patients with normal blood glucose, the risk of death in patients with hyperglycemia was 4.357 times of those with normal blood glucose at 1 year (OR = 4.357; 95 % CI 2.586-7.340), and the risks of mortality/disability was 3.117 times of those with normal blood glucose at 1 year (OR = 3.117; 95% CI 1.888-5.144). Conclusion: The blood glucose levels on admission showed significant positive correlation with the severity of the disease. The random glucose level ≥8 mmol/L on admission might be an independent risk factor influencing the prognosis of patients 1 year after spontaneous intracerebral hemorrhage.