Chemical Constituents from Stellera chamaejasme Linn / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents from the roots of Stellera chamaejasme Linn. METHODS: The 95% ethanol extract of the roots of Stellera chamaejasme Linn. was fractionalized by using petroleum ether, dichloromethane and ethyl acetate, respectively. The extraction parts were isolated by various chromatographic methods including silica gel, ODS column and preparative HPLC methods. Their structures were elucidated on the basis of spectroscopic data such as HR-ESI-MS and NMR. RESULTS: Seventeen compounds were isolated and identified as follows naringenin (1), (-)-epiafzelechin (2), (+)-epiafzelechin (3), 2,6,2',6'-tetramethoxy-4,4'-bis (2,3-epoxy-1-hydroxypropyl) biphenyl (4), 8-hydroxypluviatolide (5), (-)-syringaresinol (6), prestegane B (7), 7-hydroxycoumarin (8), daphnoretin (9), 3-(2,4-dihydroxyphenyl) propanoic acid methyl ester (10), 3,4-dihydroxystyryl alcohol (11), 3-[(1E)-3-hydroxy-1-propen-1-yl]-2, 5-dimethoxyphenyl-β-D-glucopyranoside(12), Z-octadecyl caffeate (13), 1-glyceryl linolenate (14), glycerol monolinoleate (15), 2, 3-dihydroxypropyl-9-octadecenoate (16) and β-sitosterol (17). CONCLUSION: Compounds 1, 2, 4, 5, 9-15 are reported from the genus Stellera Linn. for the first time.