Preparation, in Vitro and in Vivo evaluation of pyridostigmine bromide-phospholipids complex nanoemulsion / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 391-395, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-859192
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To prepare pyridostigmine bromide-phospholipids complex nanoemulsion (PPNE) and carry out in vitro and in vivo evaluation.METHODS:
The pyridostigmine bromide-phospholipids and PPNE were prepared by solvent evaporation method and pseudo-ternary phase diagram method, respectively. The morphology, particle size, Zeta potential, in vitro release and oral bioavailability of PPNE were evaluated.RESULTS:
The PPNE was approximately circular. The particle size and Zeta potential were 26.16 nm and -3.88 mV, respectively. The in vitro release behavior of PPNE was similar to pyridostigmine bromide. The relative oral bioavailability of PPNE was 208.1% to pyridostigmine bromide.CONCLUSION:
PPNE was successfully prepared with a simple and repeatable method, which may be a fundamental formulation for further research of pyridostigmine bromide.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo