Preparation technology of sustained-release dropping pills of trimebutine maleate / 中国药学杂志

ABSTRACT

OBJECTIVE: According to the feature that trimebutine maleate has poor aqueous solubility, low bioavailability when taken orally, short biological half-life (2.7 h), sustained-release dropping pills were prepared to achieve release slowly, reduce the blood drug concentration fluctuations and decrease frequency of use.