Huperzine a relieves acute hypobaric hypoxic-induced oxidative stress injury in rat brain / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1378-1381, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-860631
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the effects of huperzine A in ameliorating acute hypobaric hypoxic-induced spatial memory deficits and in relieving oxidative stress injury in rat brain.METHODS:
A total of 48 rats were randomly divided into four groups, the champaign group (control group), champaign + huperzine A group (0.1 mg · kg-1), high altitude group (simulated 6000 m plateau) and high altitude + huperzine A group. The Morris water maze learning and memory test, the concentration of GSH, MDA as well as the activities of CAT, SOD and LDH in hippocampus were measured and compared.RESULTS:
Compared with those of high altitude group, escape latency of high altitude + huperzine A group was significantly shorter (P < 0.05), platform crossings within 60 s was significantly more (P < 0.05), time spent in target was significantly longer (P < 0.05), GSH content, SOD and CAT activity in hippocampal tissue were significantly higher (P < 0.05), MDA and LDH activity in hippocampal tissue was significantly lower (P < 0.05), and all these changes had no significantly difference as compared with the champaign group.CONCLUSION:
Huperzine A treatment has protective effects against acute hypobaric hypoxic-induced oxidative stress injury in rat brain, and ameliorates spatial memory deficits in rats. Copyright 2012 by the Chinese Pharmaceutical Association.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo