Research Progress on Therapeutic Drug Monitoring for Thiopurine Therapy in Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Thiopurine is widely used in the management of inflammatory bowel disease (IBD). However, 15% to 30% of patients discontinue therapy because of adverse reactions or lack of clinical efficacy. Guidelines and consensus recommend that therapeutic drug monitoring (TDM) should be performed in thiopurine therapy of IBD, including detection of genetic markers before initiating treatment to predict the occurrence of adverse reactions and monitoring the metabolites to optimize the regimen. This article reviewed the research progress on TDM for thiopurine therapy in IBD.