Management of Acute Severe Ulcerative Colitis / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 321-325, 2019.
Article
em Zh
| WPRIM
| ID: wpr-861812
Biblioteca responsável:
WPRO
ABSTRACT
Acute severe ulcerative colitis (ASUC) is a medical emergency that requires prompt diagnosis and treatment. Intravenous corticosteroids are the first-line medical therapy, yet over 30% of the patients are steroid-refractory. The response to steroids should be assessed on day 3 after treatment initiation; in non-responders, treatment options including ciclosporin and infliximab, or surgery should be considered. Both ciclosporin and infliximab are effective and safe salvage therapy. Colectomy is recommended if there is no improvement following 4 to 7 days of salvage therapy. Total proctocolectomy and ileal pouch-anal anastomosis is the standard surgical procedure. A three-step approach is advocated and the postoperative complications should be cared. The diagnosis and treatment of ASUC requires multidisciplinary cooperation in order to improve prognosis and reduce mortality.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Gastroenterology
Ano de publicação:
2019
Tipo de documento:
Article