Relationships of semiquantitative parameters assessed on 18F-FDG PET/CT and EGFR mutation subtypes in lung adenocarcinoma patients / 中国介入影像与治疗学

ABSTRACT

Objective: To explore the relationships of 18F-FDG standardized uptake value (SUV)-derived parameters and mutation subtypes (deletions in exon 19 and a mutation in exon 21) in lung adenocarcinoma patients with mutant epidermal growth factor receptor (EGFR) gene. Methods Data of 64 lung adenocarcinoma patients who underwent 18F-FDG PET/CT scans and EGFR gene mutation test were collected. The relationships of subtype mutation of EGFR gene with four parameters (maximum standardized uptake value [SUVmax], average of standardized uptake value [SUVmean], metabolic tumor volume [MTV] and total lesion glycolysis [TLG]) of primary lesion based on 18F-FDG PET/CT and clinical characteristics were evaluated with univariate and multivariate Logistic regression, respectively. Results The mutant ratio of exon 19 and exon 21 was 2341. When the parameters were continuous variables, univariate Logistic regression showed exon 21 mutations were found more frequently in the EGFR-positive patients with shorter maximum diameter of primary lesion (OR=0.942, 95%CI [0.890,0.998]) and low level of MTV of primary lesion (pMTV) (OR=0.957, 95%CI [0.923,0.991]). As dichotomous variables, in univariate regression shorter maximum diameter of primary lesion (<26.5 mm OR=3.759, 95%CI [1.284,11.005]), high level SUVmean (≥4.35 OR=4.267, 95%CI [1.088,16.726]), low level pMTV (<11.2 cm3 OR=7.000, 95%CI [1.798,27.253]) would be significantly related to mutant exon 21. The multivariate Logistic regression displayed that low level of pMTV were found more frequently in exon 21 mutations (OR=8.093, P=0.041). Conclusion: The primary-lesion SUV-derived parameters from 18F-FDG PET/CT of lung adenocarcinoma patients with EGFR-gene mutation associate with the mutant subtypes (exon 19 and 21 mutation) to some extent, but this correlation might be limited.