Bone morphogenetic protein: a new direction in leukemia research / 白血病·淋巴瘤

ABSTRACT

The related changes of bone marrow microenvironment (especially mesenchymal stem cells and osteoblasts) would lead to the occurrence of leukemia. Bone morphogenetic protein (BMP) is considered to be the only known morphogenetic factor capable of inducing differentiation of mesenchymal stem cells into osteoblasts, and its role in regulating the occurrence and development of leukemia in the bone marrow microenvironment has been paid more attention. The studies found that acute myeloid leukemia derived-mesenchymal stem cells induced the morphologic transformation and resistance of K562-ADM through BMP. This paper reviews the related research of BMP in order to provide new targets and directions for the research and treatment of leukemia.