Advances in lung epithelial stem cells / 国际儿科学杂志

ABSTRACT

An in-depth understanding of the relevant cell types and mechanisms of lung regeneration has an important positive effect on the prevention and treatment of lung diseases.This review summarizes the recent advances in the classification, characteristics, and mechanisms of self-renewal and differentiation of lung epithelial stem cells.Lung epithelial stem cells include basal cells, club cells, pulmonary neuroendocrine cells, bronchioloalveolar stem cells, distal airway stem cells and alveolar epithelial stem cells.Mechanisms include Wnt, notch, innate immune signaling pathways and others related to growth factors and transcription factors.