Application of 99mTc-MIBI SPECT/CT and ultrasonography in preoperative localization of secondary hyperparathyroidism / 国际生物医学工程杂志

ABSTRACT

Objective:To evaluate the value of 99mTc-MIBI SPECT/CT and ultrasonography in preoperative localization of secondary hyperpa-rathyroidism. Methods:A retrospective analysis of 85 patients with secondary hyperparathyroidism due to uremia who underwent total parathyroidectomy or total parathyroidectomy + autologous transplantation was performed. All patients underwent color Doppler ultrasound and SPECT/CT before operation. Taking the surgical pathological results as the gold standard, the significance of SPECT/CT examination and color Doppler ultrasound examination for the preoperative localization of parathyroid nodules was analyzed.Results:The sensitivity of color Doppler ultrasound and SPECT/CT for diagnosing ectopic parathyroid nodule were 70.9% and 66.9%, respectively, and the difference was not statistically significant (χ 2=2.773, P=0.428). The combined of color Doppler ultrasound and SPECT/CT was superior to the single application of color Doppler ultrasound (χ 2=5.161, P=0.023) and SPECT/CT (χ 2=3.735, P=0.041) for diagnosing ectopic parathyroid nodules. Conclusions:For SHPT patients who require parathyroidectomy, the combined application of ultrasound and SPECT/CT before surgery can improve the sensitivity and specificity of the detection of parathyroid nodules, thereby increasing the success rate of surgery.