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Recovery of Delayed Graft Function after Calcineurin Inhibitor Sparing Regimen in a Renal Transplant Patient with Calcineurin Inhibitor Toxicity: A Case Report / 대한이식학회지
Article em En | WPRIM | ID: wpr-86704
Biblioteca responsável: WPRO
ABSTRACT
The recipient candidate was a 51-year-old male with end-stage renal disease owing to diabetes mellitus. The initial immunosuppressive regimen included basiliximab for induction and tacrolimus, mycophenolate mofetil, and steroids. Urine output was 413 mL/day on the operative day and 100 mL/day on the postoperative day (POD) 1. There was no definite stenosis of the ureter or vessels. He had anuria on POD 2~4 and he had undergone hemodialysis. His serum creatinine level did not decrease. Therefore, a graft biopsy was performed on POD 4. The pathologic finding was consistent with acute calcineurin inhibitor (CNI) toxicity. There was no evidence of rejection or acute tubular necrosis. Anuria continued on POD 6; therefore, we started sirolimus instead of a CNI based regimen. Graft function was gradually recovered 1 day after reduction of CNI dose and hemodialysis was stopped. The serum creatinine level was normalized on POD 10. He was discharged on POD 21.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Anuria / Esteroides / Ureter / Biópsia / Diálise Renal / Transplante de Rim / Tacrolimo / Constrição Patológica / Calcineurina / Transplantes Limite: Humans / Male Idioma: En Revista: The Journal of the Korean Society for Transplantation Ano de publicação: 2014 Tipo de documento: Article País de publicação: COREA DEL SUR / COREIA DO SUL / KR / SOUTH KOREA
Texto completo: 1 Base de dados: WPRIM Assunto principal: Anuria / Esteroides / Ureter / Biópsia / Diálise Renal / Transplante de Rim / Tacrolimo / Constrição Patológica / Calcineurina / Transplantes Limite: Humans / Male Idioma: En Revista: The Journal of the Korean Society for Transplantation Ano de publicação: 2014 Tipo de documento: Article País de publicação: COREA DEL SUR / COREIA DO SUL / KR / SOUTH KOREA