Diagnostic value of 99Tc m-HSA SPECT/CT imaging for protein-losing enteropathy / 中华核医学与分子影像杂志

ABSTRACT

Objective:To investigate the diagnostic value of 99Tc m-human serum albumin (HSA) SPECT/CT imaging for protein-losing enteropathy. Methods:Retrospective analysis was performed on 55 patients (21 males, 34 females, age: 5-78 (46.7±13.5) years) who had hypoproteinemia and underwent 99Tc m-HSA SPECT/CT imaging in the First Affiliated Hospital of Zhengzhou University between August 2016 and August 2019. The diagnostic efficiencies of dynamic planar imaging and SPECT/CT imaging for protein-losing enteropathy were evaluated according to the clinical final diagnosis. χ2 test was used for data analysis. Results:The final clinical diagnosis confirmed 46/52 patients were with protein-losing enteropathy. The sensitivities, specificities and accuracies of 99Tc m-HSA planar imaging and SPECT/CT imaging for the diagnosis of protein-losing enteropathy were 91.30% (42/46) vs 100% (46/46), 6/9 vs 8/9, and 87.27% (48/55) vs 98.18%(54/55), respectively. The differences in sensitivity, specificity and accuracy were all statistically significant ( χ2 values: 5.73, 4.27, 5.42, all P<0.05). Conclusion:Based on 99Tc m-HSA planar dynamic imaging, SPECT/CT imaging has good diagnostic ability for intestinal protein loss and high diagnostic efficiency for protein-losing enteropathy.