Association between total cholesterol and type 2 diabetes: a prospective cohort study / 中华疾病控制杂志
Chinese Journal of Disease Control & Prevention
; (12): 380-383,479, 2020.
Article
em Zh
| WPRIM
| ID: wpr-873519
Biblioteca responsável:
WPRO
ABSTRACT
@#Objective To explore the association between total cholesterol and type 2 diabetes ( T2DM) . Methods Non-diabetic people who aged 20 to 90 years at the baseline and who had physical examination more than 2 times were screened. Comparisons of the baseline characteristics were conducted with Student-t test or Pearson chi-square test. Generalized estimating equation ( GEE) was used to analyze the effect of total cholesterol of quantiles groups ( 2.10- mmol /L,4.16- mmol /L,4.76- mmol /L and 5.42 -13.29 mmol /L) to type 2 diabetes. Results The cohort with an average age of 3.53 years per person in- cluded 12 928 subjects and 45 626 person-years. During the follow-up,447 cases of new-onset diabetes occurred and the incidence density was 9. 80‰. The high incidence of type 2 diabetes increased with the increase of total cholesterol. After adjusting the factors including age,high density lipoprotein,hypertension and obesity,based on the 2. 10- mmol /L group,the relative risk ( RR) of the 4. 16- mmol /L,4. 76- mmol/L and 5. 42-13. 29 mmol /L group were 1. 24( 95% CI 0. 83-1. 86) ,1. 75 ( 95% CI 1. 19-2. 56) and 3. 60( 95% CI 2. 51-5. 17) ,respectively. Conclusions Total cholesterol is associated with type 2 diabetes,and as the total cholesterol increases,the risk of developing type 2 diabetes increases.
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1
Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
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Observational_studies
Idioma:
Zh
Revista:
Chinese Journal of Disease Control & Prevention
Ano de publicação:
2020
Tipo de documento:
Article
País de publicação:
CHINA
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CN
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REPUBLIC OF CHINA