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Blood-retinal barrier as a converging pivot in understanding the initiation and development of retinal diseases / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2586-2594, 2020.
Article em En | WPRIM | ID: wpr-877821
Biblioteca responsável: WPRO
ABSTRACT
Clinical ophthalmologists consider each retinal disease as a completely unique entity. However, various retinal diseases, such as uveitis, age-related macular degeneration, diabetic retinopathy, and primary open-angle glaucoma, share a number of common pathogenetic pathways. Whether a retinal disease initiates from direct injury to the blood-retinal barrier (BRB) or a defect/injury to retinal neurons or glia that impairs the BRB secondarily, the BRB is a pivotal point in determining the prognosis as self-limiting and recovering, or developing and progressing to a clinical phenotype. The present review summarizes our current knowledge on the physiology and cellular and molecular pathology of the BRB, which underlies its pivotal role in the initiation and development of common retinal diseases.
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Fenótipo / Doenças Retinianas / Barreira Hematorretiniana / Retinopatia Diabética / Degeneração Macular Limite: Humans Idioma: En Revista: Chinese Medical Journal Ano de publicação: 2020 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Fenótipo / Doenças Retinianas / Barreira Hematorretiniana / Retinopatia Diabética / Degeneração Macular Limite: Humans Idioma: En Revista: Chinese Medical Journal Ano de publicação: 2020 Tipo de documento: Article