Heterogeneity of HIV-1 latent reservoirs / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2867-2873, 2020.
Article
em En
| WPRIM
| ID: wpr-877943
Biblioteca responsável:
WPRO
ABSTRACT
Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Replicação Viral
/
Linfócitos T CD4-Positivos
/
Infecções por HIV
/
HIV-1
/
Latência Viral
/
Carga Viral
Limite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2020
Tipo de documento:
Article