Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 173-177, 2020.
Article
em En
| WPRIM
| ID: wpr-878026
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND@#Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease (AD). This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population.@*METHODS@#We enrolled 55 AD patients and 55 age- and gender-matched cognitively normal (CN) subjects in a case-control study, as well as a cohort of 131 participants without subjective cognitive decline (non-AD) in a cross-sectional study. Spicy food consumption was assessed using the Food Frequency Questionnaire (FFQ). Associations of FFQ scores with cognition and CSF biomarkers of AD were analyzed.@*RESULTS@#In the case-control study, spicy food consumption was lower in AD patients than that in CNs (4.0 [4.0-8.0] vs. 8.0 [4.5-10.0], P < 0.001); FFQ scores were positively associated with Mini-Mental Status Examination scores in the total sample (r = 0.218, P = 0.014). In the cross-sectional study, the association between spicy food consumption and cognition levels was verified in non-AD subjects (r = 0.264, P = 0.0023). Moreover, higher FFQ scores were significantly associated with higher β-Amyloid (1-42) (Aβ42) levels and lower phospho-tau/Aβ42 and total tau/Aβ42 ratios in the CSF of non-AD subjects (P < 0.05).@*CONCLUSION@#Spicy food consumption is closely related to higher cognition levels and reversed AD biomarkers in the CSF, suggesting that a capsaicin-rich diet might have the potential to modify the cognitive status and cerebral pathologies associated with AD.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fragmentos de Peptídeos
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Biomarcadores
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Estudos de Casos e Controles
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Estudos Transversais
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Peptídeos beta-Amiloides
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Proteínas tau
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Cognição
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Doença de Alzheimer
Tipo de estudo:
Observational_studies
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Prevalence_studies
Limite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2020
Tipo de documento:
Article