Research progress of non-coding RNA in regulating the function of T cells in asthma / 生理学报
Acta Physiologica Sinica
; (6): 586-596, 2020.
Article
em Zh
| WPRIM
| ID: wpr-878204
Biblioteca responsável:
WPRO
ABSTRACT
Bronchial asthma (i.e. asthma) is a chronic inflammatory disease characterized by airway inflammatory response, hyperresponsiveness and airway remodeling, in which T cells play a vital role, especially T helper cells (Th cells). Non-coding RNAs (ncRNAs) are the RNAs that do not encode proteins, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are widely found in eukaryotic genomes and participate in the regulation of various biological processes. Previous studies have shown that ncRNAs play an important role in the activation and transformation of T cells and other biological processes in asthma. The specific molecular mechanism and clinical application are worth in-depth discussion. This article reviewed the research progress in regulation of miRNAs, lncRNAs and circRNAs on T cells in asthma in recent years.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Asma
/
Linfócitos T
/
RNA não Traduzido
/
MicroRNAs
/
RNA Longo não Codificante
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2020
Tipo de documento:
Article