Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention / 生理学报
Acta Physiologica Sinica
; (6): 342-352, 2021.
Article
em Zh
| WPRIM
| ID: wpr-878262
Biblioteca responsável:
WPRO
ABSTRACT
Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fator de Crescimento Insulin-Like I
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Músculo Esquelético
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Terapia por Exercício
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Fígado
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Doenças Metabólicas
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2021
Tipo de documento:
Article