Expression and Prognostic Value of Cripto-1 in Pancreatic Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 173-179, 2021.
Article
em Zh
| WPRIM
| ID: wpr-878716
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the expression of Cripto-1 in pancreatic cancer and to analyze its clinical significance. Methods Cripto-1 expression in normal pancreas,pancreatic cancer and adjacent non-tumor tissues,chronic pancreatitis tissues and other related tissues was evaluated using immunohistochemistry.The association of Cripto-1 expression with the clinicopathological characteristics and the prognostic value of Cripto-1 in patients with pancreatic cancer were analyzed. Results The expression of Cripto-1 was higher in chronic pancreatitis tissues,pancreatic cancer and its metastases than in normal pancreas(P=0.019,P=0.025,and P=0.018,respectively).Cripto-1 overexpression was correlated with poorly differentiated pancreatic cancer.The patients with Cripto-1 upregulation had shorter median survival time(8 months vs.16 months,χ
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Pancreáticas
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Prognóstico
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Biomarcadores Tumorais
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Carcinoma Ductal Pancreático
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Peptídeos e Proteínas de Sinalização Intercelular
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Proteínas Ligadas por GPI
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Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2021
Tipo de documento:
Article