Association between maternal reduced folate carrier gene polymorphisms and congenital heart disease in offspring: a case-control study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 547-554, 2021.
Article
em Zh
| WPRIM
| ID: wpr-879892
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the association between maternal reduced folate carrier (@*METHODS@#A hospital-based case-control study was conducted. The mothers of 683 infants with CHD who attended the Department of Cardiothoracic Surgery, Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group. The mothers of 740 healthy infants without any deformity who attended the hospital during the same period of time were enrolled as the control group. A questionnaire survey was performed to collect the exposure data of subjects. Venous blood samples of 5 mL were collected from the mothers for genetic polymorphism detection. A multivariate logistic regression analysis was used to evaluate the association of @*RESULTS@#After control for confounding factors, the multivariate logistic regression analysis showed that maternal @*CONCLUSIONS@#Maternal
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Estudos de Casos e Controles
/
Fatores de Risco
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Proteína Carregadora de Folato Reduzido
/
Genótipo
/
Cardiopatias Congênitas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Infant
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2021
Tipo de documento:
Article