Association between Alcohol Consumption and Serum Cortisol Levels:a Mendelian Randomization Study
Journal of Korean Medical Science
; : e195-2021.
Article
em En
| WPRIM
| ID: wpr-899865
Biblioteca responsável:
WPRO
ABSTRACT
Background@#Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated. @*Methods@#This study examined 8,922 participants from the Dong-gu Study. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as an instrumental variable for alcohol consumption. The association between the genetically predicted alcohol consumption and cortisol level was evaluated with Mendelian randomization (MR) using two-stage least squares regression. @*Results@#Alcohol consumption was positively associated with the serum cortisol level in both sexes in the observational analysis. In the MR analysis, the genetically predicted alcohol consumption was positively related to the cortisol level in men, with cortisol levels increasing by 0.18 µg/dL per drink per day. However, there was no relationship in women in the MR analysis. @*Conclusion@#The predicted alcohol consumption according to the ALDH2 rs671 polymorphism was positively related to the cortisol levels, suggesting a causal relationship between alcohol consumption and cortisol levels.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2021
Tipo de documento:
Article