CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta
Experimental & Molecular Medicine
; : 176-184, 2007.
Article
em En
| WPRIM
| ID: wpr-90615
Biblioteca responsável:
WPRO
ABSTRACT
We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR zeta-mediated signal 1. These data demonstrate the unique properties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident co-stimulatory factors.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fosforilação
/
Ativação Linfocitária
/
Receptores de Antígenos de Linfócitos T
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Linfócitos T
/
Antígenos CD
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Moléculas de Adesão Celular
/
Regulação para Baixo
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Complexo CD3
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Fosfotirosina
/
Células Jurkat
Limite:
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2007
Tipo de documento:
Article