Expression of Runt-related Transcription Factor 3 in Human Colon Cancer Cell Line HCT-116 Resistant to 5-Fluorouracil and the Mechanism of Drug Resistance / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 706-715, 2021.
Article
em Zh
| WPRIM
| ID: wpr-921529
Biblioteca responsável:
WPRO
ABSTRACT
Objective To establish a human colon cancer cell line HCT-116/5-FU resistant to 5-fluorouracil(5-FU)and explore the relationship between runt-related transcription factor 3(RUNX3)and drug resistance of colorectal cancer.Methods The human colon cancer cell line HCT-116/5-FU with resistance to 5-FU was established by low concentration gradient increment combined with high-dose intermittent shock.CCK-8 method was used to determine the half maximal inhibitory concentration(IC
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Base de dados:
WPRIM
Assunto principal:
Neoplasias do Colo
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Resistencia a Medicamentos Antineoplásicos
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Linhagem Celular Tumoral
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Subunidade alfa 3 de Fator de Ligação ao Core
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Fator 3 de Transcrição
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Fluoruracila
Limite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2021
Tipo de documento:
Article