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The Clinical Features of Metabolic Syndrome in Receptors of Hematopoietic Stem Cells / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1610-1616, 2021.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-922304
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE@#To evaluate the incidence and clinical characteristics of metabolic syndrome (MS) within one year after hematopoietic stem cell transplantation (HSCT) in order to screen the risk factors for HSCT-MS, provide early intervention and improve the long-term quality of survival of patients.@*METHODS@#The clinical follow-up data of 64 HSCT patients (survival time > 1 year) who received HSCT in our center from January 2007 to August 2018 were collected. Among them, 50 cases were allogeneic hematopoietic stem cell transplantation (allo-HSCT) and 14 cases were autologous hematopoietic stem cell transplantation (auto-HSCT). The changes of MS-related indexes and clinical characteristics before and 1, 3, 6 and 12 months after HSCT were analyzed retrospectively.@*RESULTS@#In allo-HSCT group, 14 cases were diagnosed as MS before operation, including high-density lipoprotein cholesterol (hypo-HDL-C)> hyper triglycerides(hyper-TG)> hyper fasting glucose(hyper-FBG)> abdominal obesity (AO) > hypertension. The preoperative diagnosis of MS in the auto-HSCT group was 5 cases, in the order of hyper-FBG> hyper-TG> AO> hypo-HDL-C> hypertension. Incidence of MS at 1, 3, 6 and 12 months after transplantation 19, 26, 24 and 20 cases in the allo-HSCT group, respectively; auto-HSCT group were 7, 7, 6 and 6 cases, respectively. Hyper-TG and hypo-HDL-C were prominent in both groups.@*CONCLUSION@#The incidence of HSCT-MS is significantly higher within 1 year after HSCT. Regardless of allo-HSCT and auto-HSCT, the prevention and control of HSCT-MS is emphasized as an important guarantee to improve the long-term survival quality of HSCT patients.
Assuntos
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Transplante Homólogo / Células-Tronco Hematopoéticas / Estudos Retrospectivos / Transplante de Células-Tronco Hematopoéticas / Síndrome Metabólica Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Transplante Homólogo / Células-Tronco Hematopoéticas / Estudos Retrospectivos / Transplante de Células-Tronco Hematopoéticas / Síndrome Metabólica Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo
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