Regulatory effects of miR-138 and RUNX3 on Th1/Th2 balance in peripheral blood of children with cough variant asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1044-1049, 2021.
Article
em En
| WPRIM
| ID: wpr-922389
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES@#To study the expression levels of microRNA-138 (miR-138) and Runt-related transcription factor 3 (RUNX3) in peripheral blood of children with cough variant asthma (CVA) and their regulatory effects on Th1/Th2 balance.@*METHODS@#Sixty-five children with CVA (CVA group) and 30 healthy children (control group) were enrolled. Peripheral venous blood samples were collected for both groups, and CD4@*RESULTS@#Compared with the control group, the CVA group showed significantly decreased levels of IFN-γ and IL-2 from CD4@*CONCLUSIONS@#MiR-138 regulates Th1/Th2 balance by targeting RUNX3 in children with CVA, providing a new direction for the treatment of CVA.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Asma
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Células Th2
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Células Th1
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Interleucina-13
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Tosse
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MicroRNAs
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Subunidade alfa 3 de Fator de Ligação ao Core
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Equilíbrio Th1-Th2
Limite:
Child
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Humans
Idioma:
En
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2021
Tipo de documento:
Article