Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1174-1183, 2021.
Article
em En
| WPRIM
| ID: wpr-922407
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES@#To study the effect of high-fat diet for maternal Sprague-Dawley rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.@*METHODS@#According to the diet before pregnancy and during pregnancy and lactation, maternal rats were randomly divided into four groups (@*RESULTS@#Compared with the control diet groups (CC and CH groups), the groups with high-fat diet before pregnancy (HC and HH groups) had a significant increase in body weight (@*CONCLUSIONS@#High-fat diet for rats at different stages before and after pregnancy has different effects on glucose and lipid metabolism of offspring rats, and high-fat diet before pregnancy and during pregnancy and lactation has the greatest effect. The effect of high-fat diet on glucose and lipid metabolism of offspring rats is considered associated with the changes in the expression of genes involved in glucose and lipid metabolism.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Peso Corporal
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Resistência à Insulina
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Ratos Sprague-Dawley
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Metabolismo dos Lipídeos
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Dieta Hiperlipídica
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Glucose
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Insulina
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Fígado
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2021
Tipo de documento:
Article