Synthesis and evaluation on triglyceride inhibitory activities of novel indole alkaloids / 药学学报
Acta Pharmaceutica Sinica
; (12): 433-440, 2022.
Article
em Zh
| WPRIM
| ID: wpr-922936
Biblioteca responsável:
WPRO
ABSTRACT
Three tricyclic [6,5,7] and six tetracyclic [6,5,5,5] novel indole alkaloids were synthesized and evaluated on triglyceride inhibitory activities for the first time. Among them, compound 4c showed the most potent activity with IC50 value of 6.35 μmol·L-1. Meanwhile, compound 4c also exhibited a good safety profile at the cellular level. Preliminary mechanism study indicated that 4c might increase intracellular lipid metabolism by activating AMPK. These results provide a novel family of lead compounds for the discovery of anti-NAFLD candidates.
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1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2022
Tipo de documento:
Article