The renal metabolic mechanism of salt sensitive hypertension in Dahl-SS rats / 生理学报
Acta Physiologica Sinica
; (6): 47-58, 2022.
Article
em Zh
| WPRIM
| ID: wpr-927580
Biblioteca responsável:
WPRO
ABSTRACT
The kidney is one of the main target organs involved in hypertension, and it regulates water and salt metabolism, blood volume and vascular resistance. High salt intake induces salt and water retention, persistent endothelial dysfunction and elevation of blood pressure in salt sensitive individuals. Dahl salt sensitive (Dahl-SS) rats, as a classic animal model for salt sensitive hypertension, have many similar stably inherited physiological characteristics to human with salt sensitive hypertension, such as salt sensitivity, hyperlipidemia, insulin resistance, renal failure, increased urinary protein secretion and low plasma renin activity. Based on renal physiology and biochemistry researches and multi-omics analyses in Dahl-SS rats, this review will summarize the relationship between salt sensitive hypertension and renal redox, NO, amino acids, glucose and lipid metabolism.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pressão Sanguínea
/
Cloreto de Sódio na Dieta
/
Ratos Endogâmicos Dahl
/
Hipertensão
/
Rim
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2022
Tipo de documento:
Article