Identification of a rare platelet-specific antigen HPA-10bw allele among ethnic Han Chinese population in Shandong / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 231-233, 2022.
Article
em Zh
| WPRIM
| ID: wpr-928396
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the polymorphism of human platelet antigen (HPA) system 10 among ethnic Han Chinese from Shandong, China so as to supplement the data of platelet donor bank in the region.@*METHODS@#Peripheral blood samples of platelet donors from the region were genotyped for HPA-10 alleles by PCR-sequence specific primer (PCR-SSP) and direct sequencing.@*RESULTS@#Among 1401 donors, a rare heterozygote carrier of HPA-10w (a+b+) was identified, which gave an allelic frequency of approximately 0.035%.@*CONCLUSION@#The detection of rare HPA-10bw antigen allele among ethnic Han Chinese from Shandong is useful for the diagnosis and prevention of neonatal alloimmune thrombocytopenia and post-transfusion purpura in the region.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Antígenos de Plaquetas Humanas
/
Povo Asiático
/
Alelos
/
Frequência do Gene
/
Genótipo
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Newborn
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2022
Tipo de documento:
Article