Research progress on the relationship between formyl peptide receptor 1 and plague infection / 中华地方病学杂志

ABSTRACT

Inflammatory response is an important immune mechanism of the body, formyl peptide receptor (FPR) 1 is a pattern recognition receptor expressed in immune cells, and its binding with ligands is the basis for immune cells to realize various physiological functions in infectious inflammation. FPR1 plays an important role in inflammatory response, and changes in amino acids caused by its gene polymorphism affect a variety of diseases. Plague is an inflammatory disease caused by Yersinia pestis. Yersinia pestis, its pathogen, has a strong ability of immune escape and attacks on host immune cells. In this paper, FPR structural characteristics, expression and distribution, FPR1 gene polymorphism, ligand and its relationship with plague are reviewed, with a view to further understanding the role of FPR1 in the occurrence and development of plague.