Advances in the pathogenesis of pancreaticobiliary maljunction / 中华肝胆外科杂志

ABSTRACT

Pancreaticobiliary maljunction means the common bile duct and the main pancreatic duct in the duodenal wall, or is the formation of a long common channel leading to biliopancreatic reflux, resulting a series of biliopancreatic diseases, and even the occurrence of biliary malignancy. The pathogenesis of pancreaticobiliary maljunction is complex, involving biliary fluid dynamics, the activation of phospholipase A2, protease activation, amino acids, fat metabolism, gene mutation. This paper summarized the latest study of the pathogenesis of the pancreaticobiliary maljunction to let clinicians understand pancreaticobiliary maljunction diseases, and provide new treatment ideas.