Pharmacologic Effect of Phentolamine on Norepinephrine Induced Contraction of Corpus Cavernosum / 대한비뇨기과학회지
Korean Journal of Urology
; : 662-665, 1989.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-93790
Biblioteca responsável:
WPRO
ABSTRACT
An in vitro pharmacologic study was conducted to investigate the effect of phentolamine on norepinephrine induced contraction of human corpus cavernosum. The isometric muscle tension of corpus cavernosum from 4 potent volunteers were recorded after stimulation with various concentrations of norepinephrine and phentolamine. The results are summarized as follows. Contractile response of corpus cavernosum was observed to begin in the concentration of 10(-6) M and to reach maximal level in the concentration of 10(-4)M norepinephrine. Compared to it, contractile activity of corpus cavernosum to norepinephrine was observed to be gradually decreased in response to pretreatment with phentolamine from 10(-6)M to 10(-4)M. These indicate that norepinephrine causes a dose dependent contraction of corpus cavernosum and phentolamine had a relaxant effect on norepinephrine-induced contraction of corpus cavernosum in dose dependent manner.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fentolamina
/
Voluntários
/
Norepinefrina
/
Tono Muscular
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1989
Tipo de documento:
Artigo