Programmed death-1/programmed death ligand-1 signaling pathway in idiopathic inflammatory myopathies / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 633-636, 2022.
Article
em Zh
| WPRIM
| ID: wpr-957708
Biblioteca responsável:
WPRO
ABSTRACT
After the specific binding of programmed death-1 (PD-1) to programmed death ligand 1 (PD-L1) , the PD-1/PD-L1 complex can exert a co-suppressive/co-stimulatory immunoregulatory effect, which can inhibit the activation and proliferation of T cells and their cytokine secretion, and play a key role in tumor immunity, autoimmunity and immune tolerance. This review summarizes structures and regulatory mechanisms of the PD-1/PD-L1 signaling pathway, aimming to facilitate the understanding of immune pathogenesis of idiopathic inflammatory myopathies complicated by malignant tumors, and to seek potential therapeutic targets and diagnostic strategies.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Dermatology
Ano de publicação:
2022
Tipo de documento:
Article